![]() ![]() Flavonoids in research have demonstrated inhibitory effects on gram- positive and gram-negative bacteria including some Candida species by different mechanisms. GFSE is effective at inhibiting several fungal strains, the main being Candida albicans. coli, were demonstrated to be most sensitive to GFSE. ![]() GFSE was screened against three bacterial isolates recovered from UTIs: Staphylococcus aureus, Klebsiella pneumoniae and E. In chronic cases UTIs may become resistant to antibiotic therapy, hence the reason for different treatment strategies. Bacteria known to cause urinary tract infections, which include Escherichia coli in many cases. Studies demonstrated an antimicrobial activity of GFSE against urinary tract bacteria. GFSE has been shown to disrupt the bacterial membrane and liberate cytoplasmic contents within 15 minutes at dilute concentrations. ĭata has shown GFSE as an antimicrobial against gram-negative and gram-positive organisms at dilutions found to be safe. Studies show antimicrobial activity against food pathogens including Listeria monocytogenes, Bacillus cereus and Escherichia coli. GFSE demonstrated antimicrobial activity against Helicobacter. These strains were treated with GFSE in-vitro and investigated for antibacterial activity at several time intervals, concentration levels and for tissue toxicity at the various concentrations.Īntimicrobial activities are known for their abilities to destroy microbes. Reports on GFSE show to be effective against over 800 bacterial and viral strains, 100 strains of fungus and high amounts of single and multicellular parasites. What are the Clinical Uses of Grapefruit Seed Extract?Īntibacterial activities are known for their abilities to kill or inhibit bacteria and fungi. These bioactive compounds serve as antioxidants and modulate enzymatic activity as well as protecting against disease 1. GFSE is rich in vitamin C, phenolic compounds (flavonoids, phenolic acids and coumarins) and terpenic substances (carotenoids and limonoids). GFSE exerts antioxidant, anti-inflammatory, anti-bacterial, anti-microbial, anti-viral, and cardioprotective effects 1. GFSE has been used by naturopathic physicians for over twenty years to address internal and external infections caused by parasites, viruses, bacteria, and fungus. Grapefruit seed extract (GFSE) is a citrus seed extract, the oil is extracted from the grapefruit seeds and pulp and is often an ingredient in cosmetics, culinary, pharmaceuticals, and food supplements. Dr Jacob Harich discovered the health properties of grapefruit seeds in 1919 12. Since researchers have uncovered incidences of adulterated grapefruit seed extract on the market, she does not approve the substance for internal use.Citrus paradisi (Grapefruit) is from a subtropical fruit tree that belongs to the family Rutaceae. According to Low Dog, grapefruit seed extract's potency as an antifungal and antibacterial agent has not been adequately established. Tieraona Low Dog, M.D., of the Arizona Center for Integrative Medicine Is an expert on botanical medicine. ![]() However, other doctors disagree with using grapefruit seed extract against intestinal parasites. He cautions that a cure is not guaranteed, and relapses could occur. ![]() Suggested additions to grapefruit seed extract include wormwood, mugwort, fresh pumpkin extract, oil of cloves and/or black walnut husk. Keith Scott-Mumby, who runs an alternative health website, recommends combining grapefruit seed extract with other anti-parasitics to treat infection. The recommended dosage is 100 milligrams, three times a day. Preparations of grapefruit-seed extract are sold under several different brand names, such as Parcan, Citrocidal and DF1000. ![]()
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